Bone Marrow Transplant. 2011 Nov 14. doi: 10.1038/bmt.2011.228. [Epub ahead of print]

Clinical effectiveness of hyperbaric oxygen therapy for BK-virus-associated hemorrhagic cystitis after allogeneic bone marrow transplantation.

Savva-Bordalo J, Pinho Vaz C, Sousa M, Branca R, Campilho F, Resende R, Baldaque I, Camacho O, Campos A.

Source

Bone Marrow Transplantation Unit, Portuguese Oncology Institute, Porto, Portugal.

Abstract

Late-onset hemorrhagic cystitis (HC) after allogeneic hematopoietic stem cell transplantation (HSCT) has been associated with BK virus (BKV). Antiviral drugs are of limited efficacy and the optimal treatment for HC has not yet been established. Hyperbaric oxygen (HBO) may benefit these patients. We, therefore, retrospectively evaluated the effectiveness of HBO therapy in 16 patients with HC after allogeneic HSCT. All 16 patients had macroscopic hematuria and BKV infection. Patients received 100% oxygen in a hyperbaric chamber at 2.1 atmospheres for 90 min, 5 days per week, with a median 13 treatments (range, 4-84). Fifteen patients (94%) showed complete resolution of hematuria. Median urinary DNA BKV titers declined after HBO (P<0.05). Patients started on HBO earlier after diagnosis of HC responded sooner (P<0.05). HBO was generally well tolerated and proved to be a reliable option for this difficult to manage condition.Bone Marrow Transplantation advance online publication, 14 November 2011; doi:10.1038/bmt.2011.228.

PMID:: 22080970; [PubMed - as supplied by publisher]

LinkOut - more resources

Full Text Sources

Supplemental Content

Save items

Related citations in PubMed

Primary BK virus (BKV) infection due to possible BKV transmission during bone marrow transplantation is not the major cause of hemorrhagic cystitis in transplanted children. [Pediatr Transplant. 1998]
Primary BK virus (BKV) infection due to possible BKV transmission during bone marrow transplantation is not the major cause of hemorrhagic cystitis in transplanted children.
Bogdanovic G, Priftakis P, Taemmeraes B, Gustafsson A, Flaegstad T, Winiarski J, Dalianis T. Pediatr Transplant. 1998 Nov; 2(4):288-93.
Cidofovir for BK virus-associated hemorrhagic cystitis: a retrospective study. [Clin Infect Dis. 2009]
Cidofovir for BK virus-associated hemorrhagic cystitis: a retrospective study.
Cesaro S, Hirsch HH, Faraci M, Owoc-Lempach J, Beltrame A, Tendas A, Baltadakis I, Dalle JH, Koc Y, Toporski J, et al. Clin Infect Dis. 2009 Jul 15; 49(2):233-40.
Low-dose cidofovir treatment of BK virus-associated hemorrhagic cystitis in recipients of hematopoietic stem cell transplant. [Bone Marrow Transplant. 2007]
Low-dose cidofovir treatment of BK virus-associated hemorrhagic cystitis in recipients of hematopoietic stem cell transplant.
Savona MR, Newton D, Frame D, Levine JE, Mineishi S, Kaul DR. Bone Marrow Transplant. 2007 Jun; 39(12):783-7. Epub 2007 Apr 16.
Review Full myeloablative conditioning and an unrelated HLA mismatched donor increase the risk for BK virus-positive hemorrhagic cystitis in allogeneic hematopoetic stem cell transplanted patients. [Anticancer Res. 2011]
Review Full myeloablative conditioning and an unrelated HLA mismatched donor increase the risk for BK virus-positive hemorrhagic cystitis in allogeneic hematopoetic stem cell transplanted patients.
Dalianis T, Ljungman P. Anticancer Res. 2011 Mar; 31(3):939-44.
Review A related donor and reduced intensity conditioning reduces the risk of development of BK virus-positive haemorrhagic cystitis in allogeneic haematopoetic stem cell-transplanted patients. [Anticancer Res. 2006]
Review A related donor and reduced intensity conditioning reduces the risk of development of BK virus-positive haemorrhagic cystitis in allogeneic haematopoetic stem cell-transplanted patients.
Bogdanovic G, Priftakis P, Giraud G, Dalianis T. Anticancer Res. 2006 Mar-Apr; 26(2B):1311-8.

See reviews... See all...

Recent activity

Clear Turn Off Turn On

Clinical effectiveness of hyperbaric oxygen therapy for BK-virus-associated hemo...
Clinical effectiveness of hyperbaric oxygen therapy for BK-virus-associated hemorrhagic cystitis after allogeneic bone marrow transplantation.
Bone Marrow Transplant. 2011 Nov 14. doi: 10.1038/bmt.2011.228. [Epub ahead of print]

PubMed
Effects of microendoscopy-assisted reduction and screw fixation through a single...
Effects of microendoscopy-assisted reduction and screw fixation through a single mini-incision on posterior cruciate ligament tibial avulsion fracture.
Arch Orthop Trauma Surg. 2012 Apr ;132(4):429-35. Epub 2011 Nov 13 .

PubMed
Metabolic function of a suboptimal transplanted islet mass in non-human primates...
Metabolic function of a suboptimal transplanted islet mass in non-human primates on rapamycin monotherapy.
Cell Transplant. 2011 Nov 11. [Epub ahead of print]

PubMed
α-Blockers for benign prostatic hyperplasia: the new era.
α-Blockers for benign prostatic hyperplasia: the new era.
Curr Opin Urol. 2012 Jan ;22(1):7-15.

PubMed
Improving adherence--money isn't the only thing.
Improving adherence--money isn't the only thing.
N Engl J Med. 2011 Dec 1 ;365(22):2131-3. Epub 2011 Nov 14 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Clinical effectiveness of hyperbaric oxygen therapy for BK-virus-associated hemorrhagic cystitis after allogeneic bone marrow transplantation.

Source

Abstract

LinkOut - more resources

Full Text Sources

Supplemental Content

Save items

Related citations in PubMed

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information