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Nutrition. 2012 Feb;28(2):124-6. doi: 10.1016/j.nut.2011.08.002. Epub 2011 Nov 12.

The level of arabinitol in autistic children after probiotic therapy.

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  • 1Institute of General and Ecological Chemistry, Department of Chemistry, Technical University of Lodz, Lodz, Poland.



The level of D-arabinitol (DA) and the ratio of D-/L-arabinitol (DA/LA) in the urine of children with autism were investigated. The changes in DA/LA after probiotic treatment in urine samples of children with autism were studied.


DA and LA and the DA/LA ratio were identified by capillary gas chromatography/mass spectrometry in urine before and after the probiotic therapy.


The level of DA is significantly higher (P < 0.05) in the urine of autistic children before (A) and after probiotic supplementation (A1) (160.04 ± 22.88 μmol/mmol creatinine and 89.53 ± 37.41 μmol/mmol creatinine, respectively). Nonetheless, the probiotic supplementation let to a significant decrease in DA and DA/LA and to a significant improvement in ability of concentration and carrying out orders.


The use of probiotics seems to be helpful in reducing the level of DA and the ratio of DA/LA in the urine of children with autism.

Copyright © 2012 Elsevier Inc. All rights reserved.

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