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    Biochem Biophys Res Commun. 2011 Dec 2;415(4):632-6. Epub 2011 Nov 2.

    Myostatin induces autophagy in skeletal muscle in vitro.

    Lee JY, Hopkinson NS, Kemp PR.

    Source

    Molecular Medicine Section, National Heart & Lung Institute, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.

    Abstract

    Myostatin is an important regulator of muscle mass that contributes to the loss of muscle mass in a number of chronic diseases. Myostatin is known to activate the expression of components of the ubiquitin-proteosomal pathway but its effect on the autophagic pathway is not known. We therefore analysed the effect of myostatin and TGF-β on autophagy in C2C12 cells by determining the effect of these proteins on LC3 processing, autophagosome formation and autophagy gene expression. Both myostatin and TGF-β increased LC3II expression and turnover as well as autophagosome formation (marked by the formation of puncta in LC3-GFP transfected cells). Myostatin also significantly increased the expression of ATG-4B and ULK-2 mRNA while TGF-β caused a trend towards an increase in these genes. We conclude that myostatin and TGF-β increase autophagy in skeletal muscle cells.

    Copyright © 2011 Elsevier Inc. All rights reserved.

    PMID:
    22079631
    [PubMed - indexed for MEDLINE]

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