Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Cell Div. 2011 Nov 11;6:19. doi: 10.1186/1747-1028-6-19.

Crosstalk between NDR kinase pathways coordinates cell cycle dependent actin rearrangements.

Author information

  • 1Department of Microbiology and Physiological Systems, and Program in Cell Dynamics, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA. dannel.mccollum@umassmed.edu.

Abstract

Regulation of cytoskeletal remodeling is essential for cell cycle transitions. In fission yeast two NDR kinase signaling cascades, MOR and SIN, regulate the actin cytoskeleton to promote polarized growth during interphase and cytokinesis respectively. Our understanding of how these signaling pathways are coordinated to assist transition between the two cell-cycle stages is limited. Here, we review work from our laboratory, which reveals that cross talk between the SIN and MOR pathways is required for inhibition of interphase polarity programs during cytokinesis. Given the conservation of NDR kinase signaling pathways, our results may define general mechanisms by which these pathways are coordinated in higher organisms.

PMID:
22079013
[PubMed]
PMCID:
PMC3224761
Free PMC Article

Images from this publication.See all images (2)Free text

Figure 1
Figure 2
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for BioMed Central Icon for PubMed Central
    Loading ...
    Write to the Help Desk