J Cutan Pathol. 2012 Feb;39(2):294-7. doi: 10.1111/j.1600-0560.2011.01811.x. Epub 2011 Nov 12.

Actinic granuloma occurring in an unusual association with cutaneous B-cell chronic lymphocytic leukemia.

Kauffman JA, Ivan D, Cutlan JE, Hymes SR.

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Department of Dermatology, University of Texas Health Science Center at Houston, Houston, TX, USA. juliakauffman@hotmail.com

Abstract

Granulomatous cutaneous reactions are well described in association with T-cell non-Hodgkin lymphoma and Hodgkin lymphoma, but are rarely seen in association with B-cell non-Hodgkin lymphoma or leukemia. We report a case of a 65-year-old woman with B-cell chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) who presented with multiple, tender, firm pink papules on the face, upper trunk and upper extremities 6 years after diagnosis of CLL. Biopsy revealed both palisading granulomatous dermatitis consistent with actinic granuloma and a dense perivascular lymphocytic infiltrate consistent with the patient's known history of leukemia. This is an unusual manifestation of cutaneous B-cell CLL that is rarely seen.

PMID:: 22077555; [PubMed - indexed for MEDLINE]

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