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Crit Rev Eukaryot Gene Expr. 2011;21(2):101-13.

Hdac-mediated control of endochondral and intramembranous ossification.

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  • 1Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

Abstract

Histone deacetylases (Hdacs) remove acetyl groups (CH3CO-) from ε-amino groups in lysine residues within histones and other proteins. This posttranslational (de) modification alters protein stability, protein-protein interactions, and chromatin structure. Hdac activity plays important roles in the development of all organs and tissues, including the mineralized skeleton. Bone is a dynamic tissue that forms and regenerates by two processes: endochondral and intramembranous ossification. Chondrocytes and osteoblasts are responsible for producing the extracellular matrices of skeletal tissues. Several Hdacs contribute to the molecular pathways and chromatin changes that regulate tissue-specific gene expression during chondrocyte and osteoblast specification, maturation, and terminal differentiation. In this review, we summarize the roles of class I and class II Hdacs in chondrocytes and osteoblasts. The effects of small molecule Hdac inhibitors on the skeleton are also discussed.

PMID:
22077150
[PubMed - indexed for MEDLINE]
PMCID:
PMC3218555
Free PMC Article

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