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Pest Manag Sci. 2012 Feb;68(2):276-84. doi: 10.1002/ps.2257. Epub 2011 Nov 10.

Synthesis and herbicidal activities of novel 3-(substituted benzyloxy or phenoxy)-6-methyl-4-(3-trifluoromethylphenyl)pyridazine derivatives.

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  • 1State Key Laboratory of Elemento-organic Chemistry, Research Institute of Elemento-organic Chemistry, National Engineering Research Center of Pesticide (Tianjin), Nankai University, Tianjin, China.



4-(3-Trifluoromethylphenyl)pyridazine represents a new series of compounds with bleaching and herbicidal activities.


A total of 43 novel 3-(substituted benzyloxy or phenoxy)-6-methyl-4-(3-trifluoromethylphenyl)pyridazine derivatives were synthesised, and their bleaching and herbicidal activities were evaluated through Spirodela polyrrhiza and greenhouse tests. Some compounds exhibited excellent herbicidal activities, even at a dose of 7.5 g ha(-1).


The results showed that a substituted phenoxy group at the 3-position of the pyridazine ring and the electron-withdrawing group at the para-position on the benzene ring were essential for high herbicidal activity.

Copyright © 2011 Society of Chemical Industry.

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