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    Brain Res. 1990 Jun 18;520(1-2):322-3.

    Chronic caffeine exposure enhances adenosinergic inhibition of cerebral cortical neurons.

    Lin Y, Phillis JW.

    Source

    Department of Physiology, Wayne State University School of Medicine, Detroit, MI 48201.

    Abstract

    Chronic administration of caffeine (s.c. for a period of 14 days in escalating doses of 10-70 mg/kg) increased the sensitivity of rat cerebral cortical neurons to the inhibitory action of microiontophoretically applied adenosine. The sensitivity of spontaneously firing rat cerebral cortical neurons in caffeine-treated animals was compared with that of saline-treated controls using the same multiple-barrel micropipettes tested on the same day. Adenosine sensitivity was determined by the I.T50 method. The I.T50 value for 134 neurons in the caffeine-treated rats of 130.77 +/- 4.33 (S.E.M.) was significantly (P less than 0.001) different to that of 136 neurons in the saline-treated control rats (222.16 +/- 6.68), indicating a supersensitivity to adenosine in neurons which had been chronically exposed to caffeine.

    PMID:
    2207640
    [PubMed - indexed for MEDLINE]

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