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Biomed Opt Express. 2011 Nov 1;2(11):3037-46. doi: 10.1364/BOE.2.003037. Epub 2011 Oct 6.

Micrometer axial resolution OCT for corneal imaging.

Abstract

An optical coherence tomography (OCT) for high axial resolution corneal imaging is presented. The system uses 375 nm bandwidth (625 to 1000 nm) from a broadband supercontinuum light source. The system was developed in free space to minimize image quality degradation due to dispersion. A custom-designed spectrometer based on a Czerny Turner configuration was implemented to achieve an imaging depth of 1 mm. Experimentally measured axial resolution was 1.1 μm in corneal tissue and had a good agreement with the theoretically calculated resolution from the envelope of the spectral interference fringes. In vivo imaging was carried out and thin corneal layers such as the tear film and the Bowman's layer were quantified in normal, keratoconus, and contact lens wearing eyes, indicating the system's suitability for several ophthalmic applications.

KEYWORDS:

(170.0110) Imaging systems; (170.4460) Ophthalmic optics and devices; (170.4500) Optical coherence tomography

PMID:
22076265
[PubMed]
PMCID:
PMC3207373
Free PMC Article

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