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Cell Death Differ. 2012 Jan;19(1):36-41. doi: 10.1038/cdd.2011.155. Epub 2011 Nov 11.

Regulation of CD95/Fas signaling at the DISC.

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  • 1Division of Immunogenetics, Tumorimmunology Program German Cancer Research Center, Heidelberg, Germany.


CD95 (APO-1/Fas) is a member of the death receptor (DR) family. Stimulation of CD95 leads to induction of apoptotic and non-apoptotic signaling pathways. The formation of the CD95 death-inducing signaling complex (DISC) is the initial step of CD95 signaling. Activation of procaspase-8 at the DISC leads to the induction of DR-mediated apoptosis. The activation of procaspase-8 is blocked by cellular FLICE-inhibitory proteins (c-FLIP). This review is focused on the role in the CD95-mediated signaling of the death effector domain-containing proteins procaspase-8 and c-FLIP. We discuss how dynamic cross-talk between procaspase-8 and c-FLIP at the DISC regulates life/death decisions at CD95.

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