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J Immunol. 2011 Dec 15;187(12):6256-67. doi: 10.4049/jimmunol.1102028. Epub 2011 Nov 9.

Contact-dependent T cell activation and T cell stopping require talin1.

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  • 1Program in Cellular and Molecular Biology, University of Wisconsin, Madison, WI 53705, USA.


T cell-APC contact initiates T cell activation and is maintained by the integrin LFA-1. Talin1, an LFA-1 regulator, localizes to the immune synapse (IS) with unknown roles in T cell activation. In this study, we show that talin1-deficient T cells have defects in contact-dependent T cell stopping and proliferation. Although talin1-deficient T cells did not form stable interactions with APCs, transient contacts were sufficient to induce signaling. In contrast to prior models, LFA-1 polarized to T cell-APC contacts in talin1-deficient T cells, but vinculin and F-actin polarization at the IS was impaired. These results indicate that T cell proliferation requires sustained, talin1-mediated T cell-APC interactions and that talin1 is necessary for F-actin polarization and the stability of the IS.

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