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J Clin Microbiol. 2012 Jan;50(1):142-4. doi: 10.1128/JCM.05177-11. Epub 2011 Nov 9.

Clostridium difficile mixed infection and reinfection.

Author information

  • 1NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, United Kingdom. david.eyre@ndm.ox.ac.uk

Abstract

Isolates from consecutive Clostridium difficile infection (CDI) fecal samples underwent multilocus sequence typing. Potential reinfections with different genotypes were identified in 88/560 (16%) sample pairs taken 1 to 1,414 days (median, 24; interquartile range [IQR], 1 to 52 days) apart; odds of reinfection increased by 58% for every doubling of time between samples. Of 109 sample pairs taken on the same day, 3 (3%) had different genotypes. Considering samples 0 to 7 days apart as the same CDI, 7% of cases had mixed infections with >1 genotype.

PMID:
22075589
[PubMed - indexed for MEDLINE]
PMCID:
PMC3256686
Free PMC Article

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