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Int J Radiat Oncol Biol Phys. 2012 Feb 1;82(2):508-18. doi: 10.1016/j.ijrobp.2011.08.008. Epub 2011 Nov 9.

Treatment of locally advanced pancreatic cancer: the role of radiation therapy.

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  • 1Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520-8040, USA.


Pancreatic cancer remains associated with an extremely poor prognosis. Surgical resection can be curative, but the majority of patients present with locally advanced or metastatic disease. Treatment for patients with locally advanced disease is controversial. Therapeutic options include systemic therapy alone, concurrent chemoradiation, or induction chemotherapy followed by chemoradiation. We review the evidence to date regarding the treatment of locally advanced pancreatic cancer (LAPC), as well as evolving strategies including the emerging role of targeted therapies. We propose that if radiation is used for patients with LAPC, it should be delivered with concurrent chemotherapy and following a period of induction chemotherapy.

Copyright © 2012 Elsevier Inc. All rights reserved.

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