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Dev Cell. 2011 Nov 15;21(5):810-2. doi: 10.1016/j.devcel.2011.10.016.

Phosphatidylinositol synthase and diacylglycerol platforms bust a move.

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  • 1Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7090, USA. vytas@med.unc.edu

Abstract

Kim et al. (2011) challenge the dogma that phosphatidylinositol synthesis is restricted to the endoplasmic reticulum (ER) by showing that a mobile membrane compartment transports phosphatidylinositol synthase from the ER to numerous cellular compartments, including the plasma membrane. These findings significantly impact our view of phosphoinositide signaling in the cell.

Copyright © 2011 Elsevier Inc. All rights reserved.

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PMID:
22075144
[PubMed]
PMCID:
PMC3242638
Free PMC Article

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