Format

Send to

Choose Destination
See comment in PubMed Commons below
J Clin Psychiatry. 2011 Oct;72(10):e32. doi: 10.4088/JCP.10027tx3cc.

Moderators of antidepressant response in major depression.

Author information

  • 1Department of Psychiatry, Vanderbilt School of Medicine, Nashville, Tennessee, USA.

Abstract

Moderators are baseline variables that predict response to a treatment. Prognostic moderators predict response to all treatments, whereas prescriptive moderators predict differential response to particular treatments. In patients with major depressive disorder, prognostic variables include having anxious or chronic depression, living alone, and having psychiatric comorbidities. Prescriptive variables include gender, menopausal status, age and age at onset, depressive subtype, severity, and chronicity. Recognizing these variables can help clinicians better predict patients' response to treatment, select effective treatments for individual patients, and move patients to the next treatment step when response is inadequate.

© Copyright 2011 Physicians Postgraduate Press, Inc.

[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Physicians Postgraduate Press, Inc.
    Loading ...
    Write to the Help Desk