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J Biol Chem. 2012 Jan 13;287(3):1642-8. doi: 10.1074/jbc.R111.304428. Epub 2011 Nov 10.

Loss of daylight vision in retinal degeneration: are oxidative stress and metabolic dysregulation to blame?

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  • 1Department of Ophthalmology and Gene Therapy Center, University of Massachusetts Medical School, Worcester, Massachusetts 01606, USA.


Retinitis pigmentosa is characterized by loss of night vision, followed by complete blindness. Over 40 genetic loci for retinitis pigmentosa have been identified in humans, primarily affecting photoreceptor structure and function. The availability of excellent animal models allows for a mechanistic characterization of the disease. Metabolic dysregulation and oxidative stress have been found to correlate with the loss of vision, particularly in cones, the type of photoreceptors that mediate daylight and color vision. The evidence that these problems actually cause loss of vision and potential therapeutic approaches targeting them are discussed.

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