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Int J Mol Sci. 2011;12(10):6544-65. doi: 10.3390/ijms12106544. Epub 2011 Oct 6.

ATP-dependent chromatin remodeling factors and their roles in affecting nucleosome fiber composition.

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  • 1Division of Molecular Biology, Innsbruck Medical University, Biocenter, Fritz-Pregl Strasse 3, 6020 Innsbruck, Austria; E-Mails: (P.P.); (A.Z.).


ATP-dependent chromatin remodeling factors of the SNF2 family are key components of the cellular machineries that shape and regulate chromatin structure and function. Members of this group of proteins have broad and heterogeneous functions ranging from controlling gene activity, facilitating DNA damage repair, promoting homologous recombination to maintaining genomic stability. Several chromatin remodeling factors are critical components of nucleosome assembly processes, and recent reports have identified specific functions of distinct chromatin remodeling factors in the assembly of variant histones into chromatin. In this review we will discuss the specific roles of ATP-dependent chromatin remodeling factors in determining nucleosome composition and, thus, chromatin fiber properties.


centromere; chromatin; chromatin assembly; chromatin remodeling factor; histone variant; linker histone

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