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    Stat Methods Med Res. 2011 Nov 8. [Epub ahead of print]

    Extension of the modified Poisson regression model to prospective studies with correlated binary data.

    Source

    Department of Epidemiology & Biostatistics, and Robarts Clinical Trials of Robarts Research Institute, Schulich School of Medicine & Dentistry, Canada.

    Abstract

    The Poisson regression model using a sandwich variance estimator has become a viable alternative to the logistic regression model for the analysis of prospective studies with independent binary outcomes. The primary advantage of this approach is that it readily provides covariate-adjusted risk ratios and associated standard errors. In this article, the model is extended to studies with correlated binary outcomes as arise in longitudinal or cluster randomization studies. The key step involves a cluster-level grouping strategy for the computation of the middle term in the sandwich estimator. For a single binary exposure variable without covariate adjustment, this approach results in risk ratio estimates and standard errors that are identical to those found in the survey sampling literature. Simulation results suggest that it is reliable for studies with correlated binary data, provided the total number of clusters is at least 50. Data from observational and cluster randomized studies are used to illustrate the methods.

    PMID:
    22072596
    [PubMed - as supplied by publisher]

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