Br J Dermatol. 1990 Sep;123(3):305-12.

Elastic fibre damage induced by low-dose D-penicillamine.

Dalziel KL, Burge SM, Frith PA, Ryan TJ, Mowat A.

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Department of Dermatology, Slade Hospital, Oxford, U.K.

Abstract

We have studied 23 patients receiving penicillamine for the treatment of rheumatoid arthritis to determine the prevalence of penicillamine-induced elastosis. One female patient had pseudoxanthoma elasticum-like skin changes and bramble-bush elastosis without calcification in the involved skin. Penicillamine elastosis was present in the joint capsule in 62% of eight patients or 64% of II joints examined and was detected in joint capsules after as little as I year of treatment.

PMID:: 2206970; [PubMed - indexed for MEDLINE]

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Penicillamine

MW: 149.21 g/mol

MF: C₅H₁₁NO₂S

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Elastic fibre damage induced by low-dose D-penicillamine.

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