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Toxins (Basel). 2010 Jul;2(7):1913-27. doi: 10.3390/toxins2071913. Epub 2010 Jul 23.

NetB, a pore-forming toxin from necrotic enteritis strains of Clostridium perfringens.

Author information

  • 1CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria 3220, Australia. Anthony. Keyburn@csiro.au

Abstract

The Clostridium perfringens necrotic enteritis B-like toxin (NetB) is a recently discovered member of the β-barrel pore-forming toxin family and is produced by a subset of avian C. perfringens type A strains. NetB is cytotoxic for avian cells and is associated with avian necrotic enteritis. This review examines the current state of knowledge of NetB: its role in pathogenesis, its distribution and expression in C. perfringens and its vaccine potential.

KEYWORDS:

NetB; Clostridium perfringens; necrotic enteritis; pore-forming toxin

PMID:
22069665
[PubMed - indexed for MEDLINE]
PMCID:
PMC3153261
Free PMC Article

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