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Endokrynol Pol. 2011;62(5):429-35.

Relation of leptin, adiponectin and insulin resistance to bone mineral density in type 2 diabetic postmenopausal women.

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  • 1Department of Internal Medicine, Division of Endocrinology and Metabolism, Faculty of Medicine, Suleyman Demirel University, Turkey.

Abstract

BACKGROUND:

Our aim is to identify the relation of leptin, adiponectin and insulin resistance to bone mineral density (BMD) in type 2 diabetic postmenopausal women and compare it with that experienced by nondiabetics.

MATERIAL AND METHODS:

Seventy six postmenopausal female patients were included in the study. Postmenopausal type 2 diabetic (n = 19) and nondiabetic patients (n = 19) with spine and/or hip BMD T score lower than -2 were included in the study, and postmenopausal type 2 diabetic (n = 20) and nondiabetic women (n = 18) with normal BMD (T score > -1) were selected as control groups. Those receiving therapy for osteoporosis, over the age of 65, those who had a disease and were taking a medication that could affect bone metabolism were excluded. Biochemical tests, as well as leptin, adiponectin and insulin levels, were measured and insulin resistance was calculated using the HOMA test.

RESULTS:

There was no correlation between low BMD and leptin, adiponectin and insulin resistance. There was only a negative correlation between leptin and femur Ward's triangle BMD.

CONCLUSION:

Further large-scale studies must to be performed in order to analyse the effects of leptin, adiponectin and insulin resistance on bone metabolism in type 2 diabetic patients.

PMID:
22069104
[PubMed - indexed for MEDLINE]
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