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Contraception. 2012 Mar;85(3):288-93. doi: 10.1016/j.contraception.2011.09.001. Epub 2011 Oct 11.

Oral contraceptive and progestin-only use correlates to tissue tumor marker expression in women with cervical intraepithelial neoplasia.

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  • 1Department of Obstetrics and Gynecology, Falun Hospital, 79182 Falun, Sweden. raghad.samir@ltdalarna.se

Abstract

BACKGROUND:

The study was conducted to investigate correlations between combined oral contraceptive (COC), any progestin-only contraceptive, medicated intrauterine device (MID) or systemic progestin-only (Syst-P) use and tumor marker expression in cervical intraepithelial neoplasia compared to nonusers.

STUDY DESIGN:

One-hundred ninety-five women of fertile age with cervical biopsies ranging histologically from normal epithelium to carcinoma in situ were recruited consecutively. Combined oral contraceptive, Syst-P and MID users were investigated according to the expression of 11 tumor markers.

RESULTS:

Overexpression of cyclooxygenase-2 (Cox-2) was observed in COC users, while interleukin 10 was underexpressed. When users of progestogen-only contraceptives were analyzed, there was a lower expression of cytokeratin 10 and interleukin 10. When only MID users were analyzed, a high expression of p53 was found. Expression of Cox-2, p53 and retinoblastoma protein differed between COC and MID users.

CONCLUSION:

The study showed molecular alterations, which, in general, have not been studied previously in COC users and have never been studied in progestogen-only users. These biological events might be involved in epidemiological correlations found between hormonal contraceptive use and cervical neoplasms.

Copyright © 2012 Elsevier Inc. All rights reserved.

PMID:
22067748
[PubMed - indexed for MEDLINE]
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