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Korean J Hematol. 2011 Sep;46(3):203-6. doi: 10.5045/kjh.2011.46.3.203. Epub 2011 Sep 30.

A case of follicular B-cell lymphoma treated using clarithromycin.

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  • 1Department of General Medicine, Hokkaido Social Insurance Hospital, Sapporo, Japan.

Abstract

We report a case of follicular B-cell lymphoma (FL) treated successfully using clarithromycin (CAM). A 44-year-old man who presented with lymphadenopathy was diagnosed with FL after a histological examination of his biopsy specimens. He was administered chemotherapy with R-CHOP (rituximab, cyclophosphamide, adriamycin, vincristine, and prednisolone) following which stable disease was achieved. However, the subsequent clinical course showed partial remission of FL and stable disease with tumor regrowth, each of which was treated with chemotherapeutic regimens. Since the patient was diagnosed with leukocytopenia, he could not undergo chemotherapy for the third regrowth; hence, he was administered CAM. His lymphadenopathy regressed and the levels of soluble interleukin 2-receptor decreased. This case shows that treatment using CAM may be effective in some cases of FL.

KEYWORDS:

Apoptosis; B-cell lymphoma; Clarithromycin; Macrolide; bcl-2

PMID:
22065978
[PubMed]
PMCID:
PMC3208206
Free PMC Article
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