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RNF34 is a cold-regulated E3 ubiquitin ligase for PGC-1α and modulates brown fat cell metabolism.
Wei P, Pan D, Mao C, Wang YX.
Mol Cell Biol. 2012 Jan;32(2):266-75. Epub 2011 Nov 7.
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SCFCdc4 acts antagonistically to the PGC-1alpha transcriptional coactivator by targeting it for ubiquitin-mediated proteolysis.
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