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1: Arch Toxicol. 1990;64(5):412-3.Links

Effects of CGS 9896 in acute experimental intoxication with fluostigmine.

Rump S, Raszewski W, Gidynska T, Galecka E.

Department of Pharmacology and Toxicology, Military Institute of Hygiene and Epidemiology, Warsaw, Poland.

The therapeutic effectiveness of CGS 9896, a novel potent anxiolytic and anticonvulsant, in organophosphate intoxication was studied. It was demonstrated that this drug, used as an adjunct to a mixture of atropine and obidoxime, led to a rise in the LD50 of fluostigmine in mice of more than 150 times and more than 138 times for 2 and 24 h, respectively. After 24 h, this effect was twice that of diazepam, which served as a reference drug.

PMID: 2206111 [PubMed - indexed for MEDLINE]

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