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    Cancer Res. 2012 Jan 1;72(1):154-64. Epub 2011 Nov 4.

    A combined array-based comparative genomic hybridization and functional library screening approach identifies mir-30d as an oncomir in cancer.

    Li N, Kaur S, Greshock J, Lassus H, Zhong X, Wang Y, Leminen A, Shao Z, Hu X, Liang S, Katsaros D, Huang Q, Bützow R, Weber BL, Coukos G, Zhang L.

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    Ovarian Cancer Research Center and Department of Obstetrics & Gynecology, University of Pennsylvania, Wistar Institute, Philadelphia, Pennsylvania, USA.

    Abstract

    Oncomirs are microRNAs (miRNA) that acts as oncogenes or tumor suppressor genes. Efficient identification of oncomirs remains a challenge. Here we report a novel, clinically guided genetic screening approach for the identification of oncomirs, identifying mir-30d through this strategy. mir-30d regulates tumor cell proliferation, apoptosis, senescence, and migration. The chromosomal locus harboring mir-30d was amplified in more than 30% of multiple types of human solid tumors (n = 1,283). Importantly, higher levels of mir-30d expression were associated significantly with poor clinical outcomes in ovarian cancer patients (n = 330, P = 0.0016). Mechanistic investigations suggested that mir-30d regulates a large number of cancer-associated genes, including the apoptotic caspase CASP3. The guided genetic screening approach validated by this study offers a powerful tool to identify oncomirs that may have utility as biomarkers or targets for drug development.

    ©2011 AACR.

    PMID:
    22058146
    [PubMed - indexed for MEDLINE]

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