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Nat Med. 2011 Nov 6;17(12):1680-4. doi: 10.1038/nm.2555.

Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo.

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  • 1Wellman Center for Photomedicine, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, USA.

Abstract

Advancing understanding of human coronary artery disease requires new methods that can be used in patients for studying atherosclerotic plaque microstructure in relation to the molecular mechanisms that underlie its initiation, progression and clinical complications, including myocardial infarction and sudden cardiac death. Here we report a dual-modality intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo using a combination of optical frequency domain imaging (OFDI) and near-infrared fluorescence (NIRF) imaging. By providing simultaneous molecular information in the context of the surrounding tissue microstructure, this new catheter could provide new opportunities for investigating coronary atherosclerosis and stent healing and for identifying high-risk biological and structural coronary arterial plaques in vivo.

PMID:
22057345
[PubMed - indexed for MEDLINE]
PMCID:
PMC3233646
Free PMC Article

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