Abstract
In the course of screening for antioxidative carotenoids from bacteria, we isolated and identified a novel carotenoid, OH-chlorobactene glucoside hexadecanoate (4), and rare carotenoids, OH-chlorobactene glucoside (1), OH-γ-carotene glucoside (2) and OH-4-keto-γ-carotene glucoside hexadecanoate (3) from Rhodococcus sp. CIP. The singlet oxygen ((1)O(2)) quenching model of these carotenoids showed potent antioxidative activities IC(50) 14.6 µM for OH-chlorobactene glucoside hexadecanoate (4), 6.5 µM for OH-chlorobactene glucoside (1), 9.9 µM for OH-γ-carotene glucoside (2) and 7.3 µM for OH-4-keto-γ-carotene glucoside hexadecanoate (3).
MeSH terms
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Antioxidants / chemistry*
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Antioxidants / isolation & purification
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Antioxidants / pharmacology
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Carotenoids / chemistry*
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Carotenoids / isolation & purification
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Carotenoids / pharmacology
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Glucosides / chemistry*
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Glucosides / isolation & purification
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Glucosides / pharmacology
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Inhibitory Concentration 50
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Molecular Structure
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Oxidative Stress
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Palmitates / chemistry*
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Palmitates / isolation & purification
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Palmitates / pharmacology
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Phylogeny
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RNA, Ribosomal, 16S / genetics
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Rhodococcus / chemistry*
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Rhodococcus / classification
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Singlet Oxygen / chemistry
Substances
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Antioxidants
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Glucosides
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OH-chlorobactene glucoside
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OH-chlorobactene glucoside hexadecanoate
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OH-gamma-carotene glucoside
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Palmitates
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RNA, Ribosomal, 16S
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Singlet Oxygen
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Carotenoids