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Curr Opin Neurobiol. 2012 Feb;22(1):34-44. doi: 10.1016/j.conb.2011.10.013. Epub 2011 Nov 3.

Intracellular recording in behaving animals.

Author information

  • 1Department of Otolaryngology, NYU School of Medicine, 522 First Ave., New York, NY 10016, USA. mlong@nyumc.org

Abstract

Electrophysiological recordings from behaving animals provide an unparalleled view into the functional role of individual neurons. Intracellular approaches can be especially revealing as they provide information about a neuron's inputs and intrinsic cellular properties, which together determine its spiking output. Recent technical developments have made intracellular recording possible during an ever-increasing range of behaviors in both head-fixed and freely moving animals. These recordings have yielded fundamental insights into the cellular and circuit mechanisms underlying neural activity during natural behaviors in such areas as sensory perception, motor sequence generation, and spatial navigation, forging a direct link between cellular and systems neuroscience.

Copyright © 2011 Elsevier Ltd. All rights reserved.

PMID:
22054814
[PubMed - indexed for MEDLINE]
PMCID:
PMC3408887
Free PMC Article
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