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Appl Biochem Biotechnol. 2012 Jan;166(1):64-71. doi: 10.1007/s12010-011-9404-y. Epub 2011 Nov 4.

Sox9 is upstream of microRNA-140 in cartilage.

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  • 1Department of Orthopaedic Surgery, Shinshu University School of Medicine, Matsumoto, Japan.


MicroRNA-140 (miR-140) is specifically expressed in developing cartilage tissues. We have previously reported that miR-140 plays an important role during palatal cartilage development by modulating platelet-derived growth factor receptor alpha (pdgfra) in zebrafish. However, the regulatory mechanism of miR-140 in cartilage is still unknown. Using developing zebrafish, sox9a mutant (sox9a-/-) and sox9b mutant (sox9b-/-) zebrafish and SOX9 small interfering RNA in human chondrocytes, T/C-28 cells, we found that miR-140 is regulated by the cartilage master transcription regulator Sox9 in zebrafish and mammalian cells.

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