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Viruses. 2011 Feb;3(2):160-71. doi: 10.3390/v3020160. Epub 2011 Feb 22.

Flavivirus cell entry and membrane fusion.

Abstract

Flaviviruses, such as dengue virus and West Nile virus, are enveloped viruses that infect cells through receptor-mediated endocytosis and fusion from within acidic endosomes. The cell entry process of flaviviruses is mediated by the viral E glycoprotein. This short review will address recent advances in the understanding of flavivirus cell entry with specific emphasis on the recent study of Zaitseva and coworkers, indicating that anionic lipids might play a crucial role in the fusion process of dengue virus [1].

KEYWORDS:

West Nile virus; anionic lipids; cell entry; dengue; flavivirus; membrane fusion; negatively charged lipids; receptor

PMID:
22049308
[PubMed - indexed for MEDLINE]
PMCID:
PMC3206597
Free PMC Article
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