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J Clin Endocrinol Metab. 2012 Jan;97(1):E161-4. doi: 10.1210/jc.2011-1697. Epub 2011 Nov 2.

Circulating anti-Mullerian hormone levels in adult men are under a strong genetic influence.

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  • 1Obesity Research Unit, Helsinki University Central Hospital, FI-00029 Helsinki, Finland.

Abstract

CONTEXT:

The determinants of serum anti-Müllerian hormone (AMH) levels in adult men remain unclear.

OBJECTIVE:

The objective of the study was to investigate the genetic and environmental components in determining postpubertal AMH levels in healthy men.

DESIGN AND PARTICIPANTS:

Serum AMH levels, body mass index (BMI), and fat mass (dual energy x-ray absorptiometry) were measured in 64 healthy male (23 monozygotic and 41 dizygotic) twin pairs.

RESULTS:

Postpubertal AMH levels were highly genetically determined (broad sense heritability 0.92, 95% confidence interval 0.83-0.96). AMH correlated negatively with BMI (r = -0.26, P = 0.030) and fat mass (r = -0.23, P = 0.048). As AMH, BMI had a high heritability (0.68, 95% confidence interval 0.39-0.83), but no genetic correlation was observed between them.

CONCLUSIONS:

AMH levels in men after puberty are under a strong genetic influence. Twin modeling suggests that AMH and BMI are influenced by different sets of genes.

PMID:
22049172
[PubMed - indexed for MEDLINE]
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