Mutat Res. 1990 Sep-Nov;236(2-3):277-87.

Eukaryotic DNA ligases.

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Imperial Cancer Research Fund, Clare Hall Laboratories, South Mimms, Herts., Great Britain.

Abstract

Recent studies on eukaryotic DNA ligases are briefly reviewed. The two distinguishable enzymes from mammalian cells, DNA ligase I and DNA ligase II, have been purified to homogeneity and characterized biochemically. Two distinct DNA ligases have also been identified in Drosophila melanogaster embryos. The genes encoding DNA ligases from Schizosaccharomyces pombe, Saccharomyces cerevisiae and vaccinia virus have been cloned and sequenced. These 3 proteins exhibit about 30% amino acid sequence identity; the 2 yeast enzymes share 53% amino acid sequence identity or conserved changes. Altered DNA ligase I activity has been found in cell lines from patients with Bloom's syndrome, although a causal link between the enzyme deficiency and the disease has not yet been proven.

PMID:: 2204827; [PubMed - indexed for MEDLINE]

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Altered DNA ligase I activity in Bloom's syndrome cells. [Nature. 1987]
Altered DNA ligase I activity in Bloom's syndrome cells.
Chan JY, Becker FF, German J, Ray JH. Nature. 1987 Jan 22-28; 325(6102):357-9.
DNA ligase activity in human cell lines from normal donors and Bloom's syndrome patients. [Nucleic Acids Res. 1989]
DNA ligase activity in human cell lines from normal donors and Bloom's syndrome patients.
Mezzina M, Nardelli J, Nocentini S, Remault G, Sarasin A. Nucleic Acids Res. 1989 Apr 25; 17(8):3091-106.
A wild-type DNA ligase I gene is expressed in Bloom's syndrome cells. [Proc Natl Acad Sci U S A. 1991]
A wild-type DNA ligase I gene is expressed in Bloom's syndrome cells.
Petrini JH, Huwiler KG, Weaver DT. Proc Natl Acad Sci U S A. 1991 Sep 1; 88(17):7615-9.
Review Mammalian DNA ligases. [Bioessays. 1997]
Review Mammalian DNA ligases.
Tomkinson AE, Levin DS. Bioessays. 1997 Oct; 19(10):893-901.
Review DNA ligases in the repair and replication of DNA. [Mutat Res. 2000]
Review DNA ligases in the repair and replication of DNA.
Timson DJ, Singleton MR, Wigley DB. Mutat Res. 2000 Aug 30; 460(3-4):301-18.

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Cited by 11 PubMed Central articles

The genome of Melanoplus sanguinipes entomopoxvirus. [J Virol. 1999]
The genome of Melanoplus sanguinipes entomopoxvirus.
Afonso CL, Tulman ER, Lu Z, Oma E, Kutish GF, Rock DL. J Virol. 1999 Jan; 73(1):533-52.
Bacteriophage T4 and human type I DNA ligases relax DNA under joining conditions. [Nucleic Acids Res. 1993]
Bacteriophage T4 and human type I DNA ligases relax DNA under joining conditions.
Ciarrocchi G, Lestingi M, Wright G, Montecucco A. Nucleic Acids Res. 1993 Dec 25; 21(25):5934-9.
DNA ligase III is the major high molecular weight DNA joining activity in SV40-transformed human fibroblasts: normal levels of DNA ligase III activity in Bloom syndrome cells. [Nucleic Acids Res. 1993]
DNA ligase III is the major high molecular weight DNA joining activity in SV40-transformed human fibroblasts: normal levels of DNA ligase III activity in Bloom syndrome cells.
Tomkinson AE, Starr R, Schultz RA. Nucleic Acids Res. 1993 Nov 25; 21(23):5425-30.

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