Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Commun Integr Biol. 2011 Sep;4(5):511-2. doi: 10.4161/cib.4.5.16256. Epub 2011 Sep 1.

Nuclear actin: A key player in extracellular matrix-nucleus communication.

Author information

  • Cell Culture Essentials; Life Technologies; Frederick, MD USA.

Abstract

Decades of research have shown that there is an intimate relationship between the extracellular matrix (ECM) and cellular phenotype. While the existence of this relationship remains inarguably clear, the exact details through which the extracellular matrix controls phenotypic behavior at the gene expression level are, for the most part, elusive. In a recent study on mammary epithelial cells, nuclear actin was identified as a key effector protein through which laminin Type III (LN1) attenuates RNA polymerase activity to promote growth arrest. This finding forms the basis from which one can begin to envision a mechanism through which the ECM can control nuclear function to enact changes in cell behavior. Here I will briefly discuss the current depth of knowledge with regards to the relationship between LN1 and nuclear actin and its implication in mammary epithelial cell growth and function.

KEYWORDS:

actin, epithelial, extracellular matrix, laminin, mammary, nucleus

PMID:
22046450
[PubMed]
PMCID:
PMC3204115
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for PubMed Central
    Loading ...
    Write to the Help Desk