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J Clin Invest. 2011 Nov;121(11):4210-21. doi: 10.1172/JCI45161. Epub 2011 Nov 1.

Cellular pathophysiology of ischemic acute kidney injury.

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  • 1Renal Division, Brigham and Women’s Hospital, Boston, Massachusetts, USA. joseph_bonventre@hms.harvard.edu

Abstract

Ischemic kidney injury often occurs in the context of multiple organ failure and sepsis. Here, we review the major components of this dynamic process, which involves hemodynamic alterations, inflammation, and endothelial and epithelial cell injury, followed by repair that can be adaptive and restore epithelial integrity or maladaptive, leading to chronic kidney disease. Better understanding of the cellular pathophysiological processes underlying kidney injury and repair will hopefully result in the design of more targeted therapies to prevent the injury, hasten repair, and minimize chronic progressive kidney disease.

PMID:
22045571
[PubMed - indexed for MEDLINE]
PMCID:
PMC3204829
Free PMC Article
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