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Curr Protoc Protein Sci. 2011 Nov;Chapter 12:Unit12.8. doi: 10.1002/0471140864.ps1208s66.

Detection and analysis of proteins modified by O-linked N-acetylglucosamine.

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  • 1The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Abstract

O-GlcNAc is a common post-translational modification of nuclear, mitochondrial, and cytoplasmic proteins that is implicated in the etiology of type II diabetes and Alzheimer's disease, as well as cardioprotection. This unit covers simple and comprehensive techniques for identifying proteins modified by O-GlcNAc, studying the enzymes that add and remove O-GlcNAc, and mapping O-GlcNAc modification sites.

PMID:
22045558
[PubMed - indexed for MEDLINE]
PMCID:
PMC3349994
Free PMC Article
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