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Neurologist. 2011 Nov;17(6):340-1. doi: 10.1097/NRL.0b013e31822b54d2.

Exposure to high dosage trihexyphenidyl during pregnancy for treatment of generalized dystonia: case report and literature review.

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  • 1Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, USA. Brobottom@som.umaryland.edu

Abstract

INTRODUCTION:

Trihexyphenidyl is 1 of the most effective agents for treatment of young-onset dystonia. As such, women of childbearing potential use trihexyphenidyl despite inadequate information about potential effects on pregnancy, labor, and fetal development.

CASE REPORT:

We report 2 uncomplicated pregnancies in 1 woman with early-onset, sporadic, primary generalized dystonia (DYT1 negative) treated with high dosage trihexyphenidyl and review the literature on antidystonic agents and pregnancy.

CONCLUSION:

Although there is limited data, our case demonstrates that high-dosage trihexyphenidyl treatment is not necessarily a contraindication to pregnancy.

PMID:
22045287
[PubMed - indexed for MEDLINE]
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