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Cell Microbiol. 2012 Feb;14(2):155-67. doi: 10.1111/j.1462-5822.2011.01719.x. Epub 2011 Nov 23.

Subversion of innate immune responses by bacterial hindrance of NF-κB pathway.

Author information

  • Institute of Medical Microbiology and Hospital Hygiene, Heinrich Heine University, Düsseldorf, Germany. Gaelle.LeNegrate@uniduesseldorf.de

Abstract

Bacterial infections cause substantial mortality and burden of disease globally. Induction of a strong innate inflammatory response is the first common host mechanism required for elimination of the invading pathogens. The host transcription factor, nuclear factor kappa B (NF-κB) is essential for immune activation. Conversely, bacterial pathogens have evolved strategies to interfere directly with host cell signalling by regulating or mimicking host proteins. Given the key role of NF-κB in the host inflammatory response, bacteria have expectedly developed virulence effectors interfering with NF-κB signalling pathways. In this review, we explore the bacterial mechanisms utilized to prevent effective NF-κB signalling, which in turn usurp the host inflammatory response.

© 2011 Blackwell Publishing Ltd.

PMID:
22044780
[PubMed - indexed for MEDLINE]
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