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MAGMA. 2012 Jun;25(3):233-44. doi: 10.1007/s10334-011-0284-5. Epub 2011 Oct 22.

Possibilities and limitations for high resolution small animal MRI on a clinical whole-body 3T scanner.

Author information

  • 1Medical Physics Group, Institute for Diagnostic and Interventional Radiology I, Jena University Hospital, Jena, Germany. karl-heinz.herrmann@med.uni-jena.de

Abstract

OBJECT:

To investigate the potential of a clinical 3 T scanner to perform MRI of small rodents.

MATERIALS AND METHODS:

Different dedicated small animal coils and several imaging sequences were evaluated to optimize image quality with respect to SNR, contrast and spatial resolution. As an application, optimal grey-white-matter contrast and resolution were investigated for rats. Furthermore, manganese-enhanced MRI was applied in mice with unilateral crush injury of the optic nerve to investigate coil performance on topographic mapping of the visual projection.

RESULTS:

Differences in SNR and CNR up to factor 3 and more were observed between the investigated coils. The best grey-white matter contrast was achieved with a high resolution 3D T (2)-weighted TSE (SPACE) sequence. Delineation of the retino-tectal projection and detection of defined visual pathway damage on the level of the optic nerve could be achieved by using a T (1)-weighted, 3D gradient echo sequence with isotropic resolution of (0.2 mm)(3).

CONCLUSIONS:

Experimental studies in small rodents requiring high spatial resolution can be performed by using a clinical 3 T scanner with appropriate dedicated coils.

PMID:
22042538
[PubMed - indexed for MEDLINE]
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