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Nat Methods. 2011 Oct 30;8(12):1050-2. doi: 10.1038/nmeth.1764.

Yeast one-hybrid assays for gene-centered human gene regulatory network mapping.

Author information

  • 1Program in Systems Biology, University of Massachusetts Medical School, Worcester, Massachusetts, USA. john.reece-hoyes@umassmed.edu

Abstract

Gateway-compatible yeast one-hybrid (Y1H) assays provide a convenient gene-centered (DNA to protein) approach to identify transcription factors that can bind a DNA sequence of interest. We present Y1H resources, including clones for 988 of 1,434 (69%) predicted human transcription factors, that can be used to detect both known and new interactions between human DNA regions and transcription factors.

PMID:
22037702
[PubMed - indexed for MEDLINE]
PMCID:
PMC3263363
Free PMC Article

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