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Neuroimage. 2012 Feb 1;59(3):2155-66. doi: 10.1016/j.neuroimage.2011.10.014. Epub 2011 Oct 14.

Detecting global and local hippocampal shape changes in Alzheimer's disease using statistical shape models.

Collaborators (1166)

Saradha A, Abdi H, Abdulkadir A, Acharya D, Achuthan A, Adluru N, Aghajanian J, Agrusti A, Agyemang A, Ahdidan J, Ahmad D, Ahmed S, Aisen P, Akhondi-Asl A, Aksu Y, Alberca R, Alcauter S, Alexander D, Alin A, Almeida F, Alvarez-Lineara J, Amlien I, Anand S, Anderson D, Ang A, Angersbach S, Ansarian R, Aoyama E, Appannah A, Arfanakis K, Armor T, Arrighi M, Arumughababu Sv, Arunagiri V, Ashe-McNalley C, Ashford W, Le Page A, Avants B, Aviv R, Awasthi S, Ayache N, Ayan-Oshodi M, Ayhan M, Sumana BV, Babic T, Baek Y, Bagepally B, Baird G, Baker J, Baker S, Bakker A, Barbash S, Bard J, Barker W, Bartlett J, Baruchin A, Battaglini I, Bauer C, Bayley P, Beck I, Becker J, Becker JA, Beckett L, Bednar M, Bedner A, Beg MF, Bekris L, Belaroussi B, Belloch V, Belmokhtar N, ben Ahmed O, Bender JD, Benois-Pineau J, Bhaskar U, Bienkowska K, Biffi A, Bigler E, Bilgic B, Bishop C, Bittner D, Black S, Bloss C, Bocti C, Bohorquez A, Bokde A, Boone J, Boppana M, Borrie M, Bourgeat P, Bouttout H, Bowes M, Bowman D, Bowman G, Bracard S, Braskie M, Braunewell K, Breitner J, Bresell A, Brewer J, Brickhouse M, Brickman A, Britschgi M, Broadbent S, Brogren J, Brunton S, Buchsbaum M, Buckley C, Buerger K, Bunce D, Burnham S, Burns J, Burton D, Burzykowski T, Butler T, Cabeza R, Caffery T, Cairns N, Callhoff J, Calvini P, Carbotti A, Carle A, Carmasin J, Carmichael O, Carvalho J, Casabianca J, Casanova R, Casey A, Cash D, Cataldo R, Cedarbaum J, Cella M, Celsis P, Chakravarty M, Chang I, Chao L, Charil A, Chang CW, Chemali Z, Chen K, Chen S, Chen R, Chen Q, Chen JT, Chen G, Chen J, Chen W, Cheng WC, Cheng X, Cherkas Y, Chertkow H, Cheung V, Cheung C, Chiang G, Chiao P, Chibane MB, Chida N, Chin S, Ching C, Chisholm J, Cho C, Cho Y, Choe J, Choubey S, Chowbina S, Christensen AL, Ciocia G, Clark D, Clark C, Clarkson M, Clerc S, Clunie D, Coen M, Ciombra A, Compton D, Coppola G, Coubard O, Coulin S, Cover KS, Crane P, Crans G, Croop R, Crowther D, Crum W, Cui Y, Curry C, Cutter G, Da L, Daliri MR, Damato VD, Darby E, Darkner S, Davatzikos C, DavidPrakash B, Davidson C, Davis M, de Bruijne M, De Meyer G, De Nunzio G, DeCarli C, Dechairo B, DeDuck K, Dehghan H, Delfino M, Della Rosa PA, Dellavedova L, Delpassand E, Delrieu J, DeOrchis V, Dépy Carron D, Desjardins B, deToledo-Morrell L, Devanand D, Devanarayan V, Devier D, Devous M, Dgetluck N, Di J, Di X, Diaz-Arrastia R, Dickerson B, Dickie DA, Dill V, Ding X, Dinov I, Dobosh B, Dobson H, Dodge H, Dolman A, Dolmo BC, Donohue M, Dore V, Dorflinger E, Dowling M, Dragicevic N, Dubal D, Duchesne S, Duff K, Dukart J, Durazzo T, Dutta J, DWors R, Earl N, Edula G, Elcoroaristizabal X, Emahazion T, Endres C, Epstein N, Ereshefsky L, Eskildsen S, Espinosa A, Esposito M, Ewers M, Falcone G, Fan Y, Fan J, Fan L, Farahibozorg S, Farb N, Fardo D, Farias S, Farnum M, Farrer L, Fatke B, Faux N, Feldman H, Feldman S, Feldman B, Félix Z, Fennema-Notestine C, Fernandes M, Fernandez E, Ferreira MJ, Ferrer E, Fetterman B, Figurski M, Fillit H, Finch S, Fiot JB, Flenniken D, Fletcher E, Flores C, Longmire CF, Focke N, Forman M, Forsythe A, Fox S, Fox-Bosetti S, Foxhall S, Franko E, Freeman R, Friedrich CM, Friesenhahn M, Frisoni G, Fritzsche K, Fujimoto Y, Fujiwara K, Fullerton T, Gaffour Y, Galvin B, Gamst A, Gao S, Garg G, Gaser C, Gastineau E, Gattaz W, Gaubert M, Gauthier S, Gavett B, Ge T, Gemme G, Geraci J, Gholipour F, Ghosh D, Ghosh S, Gieschke R, Gill R, Gillespie W, Gitelman D, Gkontra X, Gleason C, Glymour MM, Godbey M, Gold B, Goldberg T, Goldman J, Gonzalez-Beltran A, Goodro R, Gore C, Gorriz JM, Goto M, Grachev I, Gradkowski W, Grandey E, Grasela T, Gray K, Greenberg B, Greicius M, Grill J, Gross A, Gross A, Grydeland H, Guignot I, Guo Q, Guo LH, Guo H, Gupta V, Guyot J, Habeck C, Habte F, Haight T, Hajaj C, Hajiesmaeili M, Hajjar I, Hammarstrom P, Hampel H, Han D, Han J, Han Z, Hanna Y, Hao Y, Hardy P, Harvey D, Hasan MK, Hayashi T, Haynes JD, He H, He Y, Head D, Heckemann R, Heegaard N, Heidebrink J, Hellyer P, Helwig M, Henderson D, Herholz K, Herskovits AZ, Hess C, Hildenbrand M, Ming AY, Hobart J, Hochstetler H, Hofer S, Hoffman J, Holder D, Hollingworth P, Holmes R, Hong Q, Honigberg L, Hope T, Hoppin J, Hot P, Hou Y, Hsieh H, Hsu A, Hu X, Hu M, Hu W, Hua WY, Huang S, Huang F, Huang Z, Huang CJ, Huang CC, Huang J, Hubbard R, Huentelman M, Huppertz HJ, Hurko O, Hurt S, Hutchins J, Hwang S, Hyun J, Ifeachor E, Iglesias M, Ikari Y, Ikonomidou V, Iman A, Imani F, Immermann F, Inlow M, Inoue L, Insel P, Irizarry M, Ishibashi T, Ishii K, Ismail S, Ito K, Iturria-Medina Y, Iwatsubo T, Jacks A, Jacobson M, Jacqmin P, Jaffe C, Jagust W, Janousova E, Jara H, Jasperse B, Jedynak B, Jefferson A, Jennings JR, Jenq J, Jessen W, Jia F, Jiang T, Jiao Y, Jing H, Johnson K, Johnson S, Johnson DK, Johnson J, Jones G, Jones M, Jones R, Joshi S, Jouvent E, Juengling F, Julin P, Junjie Z, Kabilan M, Kadish B, Kairui Z, Kam HJ, Kamboh MI, Kamer A, Kanakaraj S, Kanchev V, Kaneko T, Kaneta T, Kang H, Kang JH, Kang J, Karageorgiou E, Karantzoulis S, Karlawish J, Katz E, Kaushik SS, Kauwe J, Kawakami H, Kawashima S, Kaye E, Kazemi S, Ke H, Kelleher T, Kennedy R, Keogh B, Kerchner G, Kerr D, Keshava N, Khalil I, Khalil A, Khondker Z, Kihara T, Killeen N, Killiany R, Kim D, Kim H, Kim S, Kim JH, Kim A, Kim JH, Kimberg D, Kimura T, King R, Kirby J, Kirsch W, Klimas M, Kline R, Kling M, Klopfenstein E, Koen J, Koikkalainen J, Kokomoor A, Kong X, Koppel J, Korolev I, Kotran N, Kowalczyk A, Krahnke T, Krams M, Kuceyeski A, Kuhl D, Kumar V, Roy PK, Kuo J, Labrish C, Lai S, Lakatos A, Lalonde F, Lam OK, Lampron A, Landau S, Lane R, Lane B, Langbaum J, Langford D, Lanius V, Latella M, Leahy R, an Lee J, Lee D, Lee N, Lee S, Lee D, Lee G, Lefkimmiatis S, Lemaitre H, Lenfant P, Lenz R, Leong J, Leoutsakos JM, Leung YY, Levey A, Li R, Li X, Li W, Li X, Li M, Li L, Li J, Li G, Li Q, Li Y, Li J, Li J, Li Y, Li S, Liang K, Liang K, Liang P, Liang L, Liao W, Liaquat S, Liberman G, Lin L, Lin AL, Lin F, Liu T, Liu D, Liu L, Liu H, Liu S, Liu T, Liu X, Liu S, Liu L, Liu W, Liu G, Liu T, Liu Y, Liu C, Lo R, Lobanov V, Lockhart A, Loewenstein D, Logovinsky V, Long M, Long Z, Long X, Looi J, Lu H, Lu PH, Lucena N, Lukas C, Lukic A, Luo L, Luo X, Luo X, Lynch J, Ma SM, Mackin S, Mada M, Madabhushi A, Maglio S, Mahanta MS, Maikusa N, Maldjian J, Mandal I, Manjon J, Mantri N, Manzour A, Marchewka A, Marcus D, Margolin R, Marrett S, Marshall G, Gonzalez AM, Torteya AM, Mather M, Mathis C, Mattei P, Matthews D, McArdle J, McCarroll S, McEvoy L, McGeown W, McGinnis S, McGonigle J, McIntyre J, McLaren D, McQuail J, Meadowcroft M, Meda S, Melie-Garcia L, Melrose R, Mendelson A, Mendez M, Menendez E, Meng M, Meredith J, Metti A, Meyer C, Mez J, Mickael G, Miftahof R, Mikula M, Miller M, Millikin C, Mintun M, Mirza M, Mistridis P, Mitchell M, Mitsis E, Mon A, Moore D, Morabito FC, Birgani PM, Moratal D, Morimoto B, Mormino E, Morris J, Mortamet B, Moscato P, Mueller K, Mueller S, Mukherjee S, Mulder E, Mungas D, Munir K, Murayama S, Murphy M, Myers A, Sairam N, Nagata K, Nair A, Nativio R, Nazarparvar B, Nazeri A, Nejad L, Nekooei S, Nettiksimmons J, Neu S, Ng YB, Nguyen N, Nichols T, Nicodemus K, Niecko T, Nielsen C, Nishio T, Nordstrom M, Noshad S, Notomi K, Novak N, Nutakki GC, O'Bryant S, Obisesan T, Oh J, Okonkwo O, Olde Rikkert M, Oliveira A, Oliveira J, Oliver R, Olmos S, Oltra J, Ortner M, Osadebey M, Ostrowitzki S, Overholser R, Anishiya P, Chitra PK, Pa J, Palanisamy P, Pan S, Pan Z, Pande Y, Pardo J, Pardoe H, Park Sh, Park S, Park L, Park H, Park MH, Parker C, Patel Y, Patil A, Patil M, Pawlak M, Payoux P, Pearson J, Pell G, Peng Y, Pennec X, Pepin Jl, Pereira F, Perneczky R, Petitti D, Petrella J, Peyrat JM, Ngoc PT, Phillips J, Phillips N, Pian WT, Pierson R, Piovezan M, Pipitone J, Pirraglia E, Planes X, Podhorski A, Pollari M, Pomara N, Pontecorvo M, Popov V, Poppenk J, Posner H, Potkin S, Potter G, Potter E, Poulin S, Prastawa M, Prince J, Priya A, Pruessner J, Qiu W, Qu A, Qualls CD, Quarg P, Quinlan J, Rabbia M, Rajagovindan R, Rajeesh R, Rallabandi VP, Ramadubramani V, Ramage A, Ramirez A, Randolph C, Rao A, Rao H, Rao D, Raubertas R, Ray D, Razak H, Reed B, Reid A, Reihac A, Reiner P, Reinsberger C, Restrepo L, Retico A, Rhatigan L, Rhinn H, Rhoades E, Ribbens A, Richard E, Richards J, Richter M, Riddle W, Ridgway G, Ries M, Ringman J, Rischall M, Rizk-Jackson A, Rizzi M, Robieson W, Rodriguez L, Rodriguez-Vieitez E, Rogalski E, Rogers E, Balderrama JR, Rokicki J, Romero K, Rorden C, Rosand J, Rosen O, Rosenberg P, Roubini E, Rousseau F, Rowe C, Rubin D, Rubright J, Rucinski M, Ruiz A, Rulseh A, Rusinek H, Ryan L, Saad A, Sabuncu M, Sahuquillo J, Said Y, Saito N, Sakata M, Salama M, Salazar D, Salter H, Saman S, Sanchez L, Sanders E, Sankar T, Santhamma S, Sarnel H, Sasaki T, Sasaya T, Sato H, Sattlecker M, Saumier D, Savio A, Saykin A, Scanlon B, Scharre D, Schegerin M, Schmand B, Schmansky N, Schmidt-Wilcke T, Schramm H, Schuerch M, Schwartz C, Schwartz E, Schwarz A, Schwarz J, Selnes P, Sembritzki K, Senjem M, Sevigny J, Sfikas G, Sghedoni R, Shah SK, Shahbaba B, Shams S, Shankle W, Shattuck D, Shaw L, Sheela J, Shen J, Shen Q, Shen W, Shen Q, Shera D, Sherman J, Sherva R, Shi J, Shi Y, Shi F, Shokouhi S, Shukla V, Shulman J, Sideris K, Siegel R, Silveira M, Silverman D, Sim I, Simak A, Simmons A, Simoes R, Simon A, Simon M, Simpson I, Singh N, Singh SP, Sinha N, Siuciak J, Sjögren N, Skinner J, Smith M, Smith C, Smyth T, Snow S, Snyder P, Soares H, Soldan A, Soldea O, Solomon A, Solomon P, Som S, Song Z, Song S, Sosova I, Soydemir M, Spampinato MV, Speier W, Sperling R, Renãâ S, Spies L, Springate B, Staff R, Steffener J, Stern Y, Stokman H, Straw J, Stricker N, Stühler E, Styren S, Subramanian V, Suen S, Sugishita M, Sukkar R, Sun Y, Sun J, Sun Y, Sundell K, Suzuki A, Svetnik V, Swan M, Symons S, Szigeti K, Szoeke C, Sørensen L, Genish T, Takahasi T, Takeuchi T, Tanaka S, Tanaka R, Tanchi C, Tancredi D, Tang Q, Tarnow E, Tartaglia MC, Tarver E, Tassy D, Tauber C, Taylor-Reinwald L, Teipel S, Teng E, Terriza F, Thambisetty M, Thames A, Thatavarti RS, Thiele F, Thomas C, Thomas R, Thomas B, Thompson P, Thompson W, Thornton-Wells T, Thorvaldsson V, Thurfjell L, Tokuda T, Toledo JB, Tölli T, Toma A, Tomita N, Toro R, Torrealdea P, Tosto G, Tosun D, Tousian M, Toussaint P, Toyoshiba H, Tractenberg RE, Triggs T, Trittschuh E, Trojanowski J, Trotta G, Huu TT, Truran D, Tsanas A, Tsang C, Tufail A, Tung J, Turken A, Ueda Y, Uematsu D, Ullrich L, Venkataraju KU, Umar N, Ungar L, Uzunbas G, Van de Nes J, van der Brug M, van der Lijn F, Van Hecke W, Van Horn J, Van Leemput K, Van Train K, Varkuti B, Vasanawala M, Veeraraghavan H, Vemuri P, Verma M, Videbaek C, Vidoni E, Villanueva-Meyer J, Vinyes G, Visser PJ, Vitek M, Vogel S, Voineskos A, Vos S, Vounou M, Wade S, Walsh A, Wan H, Wang T, Wang YM, Wang W, Wang A, Wang S, Wang L, Wang L, Wang Y, Wang LS, Wang L, Wang A, Wang Y, Wang X, Wang Z, Wang T, Ward M, Ward A, Watanabe T, Watson D, Webb D, Wefel J, Weiner M, Westlye LT, Wheland D, Whitcher B, White B, Whitlow C, Wilhelmsen K, Wilmot B, Wilson L, Wimsatt M, Wingo T, Wirth M, Wishart H, Wiste H, Wolf H, Wolke I, Wolz R, Wong K, Woo J, Woo E, Woods L, Worth A, Wu Y, Wu L, Wu E, Wyman B, Xiao G, Xie S, Xu Y, Xu YZ, Xu G, Xu S, Xu S, Xu J, Yamada T, Yamashita F, Yan Y, Yan P, Yan Y, Yang CY, Yang Z, Yang E, Yang G, Yang W, Yang E, Yank HD, Yang J, Yassa M, Yavorsky C, Ye BS, Ye L, Ye J, Yee L, Ying S, Yokoyama T, Young S, Young J, Younhyun J, Yu D, Yu S, Yu CQ, Yu P, Yuan Y, Yuan K, Yuan G, Yuen B, Yushkevich P, Zaborszky L, Zagorodnov V, Zagorski M, Zahodne L, Zarei M, Zawadzki R, Zeitzer J, Zelinski E, Zeskind B, Zhan S, Zhang J, Zhang L, Zhang Z, Zhang L, Zhang Z, Zhang D, Zhang H, Zhang X, Zhang T, Zhang P, Zhao J, Zhao Q, Zhao P, Zhen X, Zhijun Y, Zhou L, Zhou B, Zhou Y, Zhou S, Zhu H, Zhu W, Zhu W, Zhu X, Ziegler G, Zilka S, Zisserman A, Zito G, Zu C, Zulfigar A.

Author information

  • 1Australian e-Health Research Centre, CSIRO ICT Centre, Herston, Queensland, Australia. Kaikai.Shen@gmail.com

Abstract

The hippocampus is affected at an early stage in the development of Alzheimer's disease (AD). With the use of structural magnetic resonance (MR) imaging, we can investigate the effect of AD on the morphology of the hippocampus. The hippocampal shape variations among a population can be usually described using statistical shape models (SSMs). Conventional SSMs model the modes of variations among the population via principal component analysis (PCA). Although these modes are representative of variations within the training data, they are not necessarily discriminative on labeled data or relevant to the differences between the subpopulations. We use the shape descriptors from SSM as features to classify AD from normal control (NC) cases. In this study, a Hotelling's T2 test is performed to select a subset of landmarks which are used in PCA. The resulting variation modes are used as predictors of AD from NC. The discrimination ability of these predictors is evaluated in terms of their classification performances with bagged support vector machines (SVMs). Restricting the model to landmarks with better separation between AD and NC increases the discrimination power of SSM. The predictors extracted on the subregions also showed stronger correlation with the memory-related measurements such as Logical Memory, Auditory Verbal Learning Test (AVLT) and the memory subscores of Alzheimer Disease Assessment Scale (ADAS).

Crown Copyright © 2011. Published by Elsevier Inc. All rights reserved.

PMID:
22037419
[PubMed - indexed for MEDLINE]
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