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J Clin Virol. 2011 Dec;52 Suppl 1:S77-82. doi: 10.1016/j.jcv.2011.09.015. Epub 2011 Oct 28.

Evolution in the sensitivity of quantitative HIV-1 viral load tests.

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  • 1Roche Molecular Systems, 4300 Hacienda Drive, Pleasanton, CA, USA.


Significant advancements in molecular diagnostics have been made since the inception and application of PCR-based technologies in clinical diagnostic laboratories and the management of HIV-1 infected patients. More recently, real-time PCR has improved the overall performance of assays used for detecting and quantifying HIV-1 RNA viral load in patients undergoing antiretroviral treatment. The effects of these changes and the interpretations of the HIV-1 viral load results are discussed in this review in the context of the different assays used, the viral dynamics of the HIV-1 virus, and the recent changes to HIV-1 treatment guidelines.

Copyright © 2011 Elsevier B.V. All rights reserved.

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