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    Immunity. 2011 Oct 28;35(4):550-61.

    Mast cells condition dendritic cells to mediate allograft tolerance.

    de Vries VC, Pino-Lagos K, Nowak EC, Bennett KA, Oliva C, Noelle RJ.

    Source

    Department of Microbiology and Immunology, Dartmouth Medical School and Norris Cotton Cancer Center, Lebanon, NH 03756, USA.

    Erratum in

    • Immunity. 2011 Dec 23;35(6):1035-6.

    Abstract

    Peripheral tolerance orchestrated by regulatory T cells, dendritic cells (DCs), and mast cells (MCs) has been studied in several models including skin allograft tolerance. We now define a role for MCs in controlling DC behavior ("conditioning") to facilitate tolerance. Under tolerant conditions, we show that MCs mediated a marked increase in tumor necrosis factor (TNFα)-dependent accumulation of graft-derived DCs in the dLN compared to nontolerant conditions. This increase of DCs in the dLN is due to the local production of granulocyte macrophage colony-stimulating factor (GM-CSF) by MCs that induces a survival advantage of graft-derived DCs. DCs that migrated to the dLN from the tolerant allograft were tolerogenic; i.e., they dominantly suppress T cell responses and control regional immunity. This study underscores the importance of MCs in conditioning DCs to mediate peripheral tolerance and shows a functional impact of peripherally produced TNFα and GM-CSF on the migration and function of tolerogenic DCs.

    Copyright © 2011 Elsevier Inc. All rights reserved.

    PMID:
    22035846
    [PubMed - indexed for MEDLINE]

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