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Oral Dis. 2012 Mar;18(2):191-7. doi: 10.1111/j.1601-0825.2011.01864.x. Epub 2011 Oct 30.

Assessment of orofacial characteristics and oral pathology associated with cri-du-chat syndrome.

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  • 1Clinical Assistance in Oral Surgery, University of Seville, Seville, Spain.



To obtain a deeper insight into the difficulties individuals with cri-du-chat syndrome experience by means of the analysis of the most common features and oral pathology observed in the subjects enrolled in the study.


Intra-oral and extra-oral features of a total of 33 patients with cri-du-chat syndrome (the larger sample so far analyzed) through their clinical and photographic examination. Models, orthopantomographies, and teleradiographies have been collected to establish a pattern as accurate as possible of the oral pathology associated with these patients.


The present descriptive study shows that patients with cri-du-chat syndrome present with a series of orofacial features such as mandibular retrognathism, high palate, and variable malocclusion, more commonly anterior open-bite. Most patients also present with perioral muscle relaxation with labial incompetence and short philtrum. As regards oral pathology, these patients suffer dental erosions provoked by gastroesophageal reflux and attritions because of intense day-and-night bruxism.


The odontologists' familiarity with the orofacial pathology associated with cri-du-chat syndrome and with the specific needs such disorder conveys should improve the quality of the buccodental treatment these professionals may offer to these patients.

© 2011 John Wiley & Sons A/S.

[PubMed - indexed for MEDLINE]
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