Trends Pharmacol Sci. 1990 Aug;11(8):321-4.

Flavin-containing monooxygenases: enzymes adapted for multisubstrate specificity.

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Clayton Foundation Biochemical Institute, Austin, TX.

Abstract

Unlike all other oxidases, microsomal flavin-containing monooxygenases (FMO) discriminate between essential and foreign compounds by excluding the former rather than selectively binding the latter. As Daniel Ziegler describes here, xenobiotics that readily cross cell membranes can enter the catalytic cavity, whereas charged groups on essential metabolites that prevent their passive diffusion out of the cell also block their access to FMO. FMO appears to be ideally adapted to catalyse the detoxification of structurally diverse soft nucleophiles (e.g. alkaloids with basic side-chains and organic sulfur xenobiotics) so abundant in food derived from plants.

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Review Recent studies on the structure and function of multisubstrate flavin-containing monooxygenases. [Annu Rev Pharmacol Toxicol. 1993]
Review Recent studies on the structure and function of multisubstrate flavin-containing monooxygenases.
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Review The assessment of flavin-containing monooxygenase activity in intact animals. [Drug Metabol Drug Interact. 1996]
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