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Clin Vaccine Immunol. 2011 Dec;18(12):2183-5. doi: 10.1128/CVI.05425-11. Epub 2011 Oct 26.

Estimation of dengue virus IgM persistence using regression analysis.

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  • 1Focus Diagnostics, Inc., Cypress, CA 90630, USA. hprince@focusdx.com

Abstract

Dengue virus IgM persistence was estimated using follow-up sera from 98 patients (60 with primary infections and 38 with secondary infections) whose first-specimen IgM index was strongly positive, suggesting recent disease onset. Regression analysis of the follow-up IgM index versus days between samples yielded a trend line that reached the cut-point index (1.10) at 179 days for the primary infection group and 139 days for the secondary infection group. This difference reflected significantly higher first-sample IgM indices in primary infections than in secondary infections rather than differences in IgM decay rates.

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