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J Biomed Opt. 2011 Oct;16(10):100503. doi: 10.1117/1.3644495.

Functional photoacoustic microscopy of pH.

Author information

  • 1Washington University in St. Louis, Optical Imaging Laboratory, Department of Biomedical Engineering, One Brookings Drive, St. Louis, Missouri 63130, USA.

Abstract

pH is a tightly regulated indicator of metabolic activity. In mammalian systems, an imbalance of pH regulation may result from or result in serious illness. In this paper, we report photoacoustic microscopy (PAM) of a commercially available pH-sensitive fluorescent dye (SNARF-5F carboxylic acid) in tissue phantoms. We demonstrated that PAM is capable of pH imaging in absolute values at tissue depths of up to 2.0 mm, greater than possible with other forms of optical microscopy.

PMID:
22029342
[PubMed - indexed for MEDLINE]
PMCID:
PMC3210191
Free PMC Article

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