Format

Send to

Choose Destination
See comment in PubMed Commons below
Biol Psychol. 2012 Jan;89(1):220-31. doi: 10.1016/j.biopsycho.2011.10.013. Epub 2011 Oct 24.

Stop-signal response inhibition in schizophrenia: behavioural, event-related potential and functional neuroimaging data.

Author information

  • 1Brain and Psychological Sciences Centre, Swinburne University of Technology, Melbourne, VIC, Australia. matthewhughes@swin.edu.au

Abstract

Inhibitory control deficits are well documented in schizophrenia, supported by impairment in an established measure of response inhibition, the stop-signal reaction time (SSRT). We investigated the neural basis of this impairment by comparing schizophrenia patients and controls matched for age, sex and education on behavioural, functional magnetic resonance imaging (fMRI) and event-related potential (ERP) indices of stop-signal task performance. Compared to controls, patients exhibited slower SSRT and reduced right inferior frontal gyrus (rIFG) activation, but rIFG activation correlated with SSRT in both groups. Go stimulus and stop-signal ERP components (N1/P3) were smaller in patients, but the peak latencies of stop-signal N1 and P3 were also delayed in patients, indicating impairment early in stop-signal processing. Additionally, response-locked lateralised readiness potentials indicated response preparation was prolonged in patients. An inability to engage rIFG may predicate slowed inhibition in patients, however multiple spatiotemporal irregularities in the networks underpinning stop-signal task performance may contribute to this deficit.

Crown Copyright © 2011. Published by Elsevier B.V. All rights reserved.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk