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Anat Cell Biol. 2011 Sep;44(3):169-75. doi: 10.5115/acb.2011.44.3.169. Epub 2011 Sep 29.

Proapoptotic role of nuclear clusterin in brain.

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  • 1Department of Anatomy and Neurobiology, Medical Research Center for Neural Dysfunction, Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Korea.


Clusterin (CLU) is a multifunctional glycoprotein that has secretory and nuclear isoforms. The two isoforms are known to play opposite roles in cell survival/death. In this review, we summarize recent progress on the pro-apoptotic function of nuclear CLU in vitro and in vivo and discuss previous reports on the role of CLU in brain damage and neurodegeneration.


Apoptosis; Brain; Clusterin

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