Semin Dermatol. 1990 Jun;9(2):148-51.

Current status of podophyllotoxin for the treatment of genital warts.

Source

Department of Dermatology, University of California, San Francisco.

Abstract

An evolutionary process that began 50 years ago with a crude plant resin (podophyllum) has currently developed to the point where a fine chemical podophyllotoxin can be safely and effectively applied by patients for the treatment of external genital warts. In this brief review, the fundamental chemistry, pharmacology, and toxicology of podophyllotoxin will be reviewed, along with the sequence of clinical studies that resulted in the development of patient applied podophyllotoxin.

PMID:: 2202410; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

LinkOut - more resources

Medical

Molecular Biology Databases

PODOFILOX - HSDB

Supplemental Content

Save items

Related citations in PubMed

Podophyllotoxin 0.5% v podophyllin 20% to treat penile warts. [Genitourin Med. 1988]
Podophyllotoxin 0.5% v podophyllin 20% to treat penile warts.
Edwards A, Atma-Ram A, Thin RN. Genitourin Med. 1988 Aug; 64(4):263-5.
Topical treatment of penile condylomata acuminata with podophyllin, podophyllotoxin and colchicine. A comparative study. [Acta Derm Venereol. 1978]
Topical treatment of penile condylomata acuminata with podophyllin, podophyllotoxin and colchicine. A comparative study.
von Krogh G. Acta Derm Venereol. 1978; 58(2):163-8.
[Therapy of penile viral condylomata with 0.5% podophyllotoxin]. [G Ital Dermatol Venereol. 1990]
[Therapy of penile viral condylomata with 0.5% podophyllotoxin].
Caresana G, Del Forno C. G Ital Dermatol Venereol. 1990 Dec; 125(12):LXV-LXVIII.
Review Painting penile warts. [Drug Ther Bull. 1990]
Review Painting penile warts.
. Drug Ther Bull. 1990 Aug 6; 28(16):63-4.
Review Podophyllin office therapy against condyloma should be abandoned. [Sex Transm Infect. 2001]
Review Podophyllin office therapy against condyloma should be abandoned.
von Krogh G, Longstaff E. Sex Transm Infect. 2001 Dec; 77(6):409-12.

See reviews... See all...

Cited by 5 PubMed Central articles

Carbon tetrachloride induced kidney and lung tissue damages and antioxidant activities of the aqueous rhizome extract of Podophyllum hexandrum. [BMC Complement Altern Med. 2011]
Carbon tetrachloride induced kidney and lung tissue damages and antioxidant activities of the aqueous rhizome extract of Podophyllum hexandrum.
Ganie SA, Haq E, Hamid A, Qurishi Y, Mahmood Z, Zargar BA, Masood A, Zargar MA. BMC Complement Altern Med. 2011 Feb 28; 11:17. Epub 2011 Feb 28.
Podophyllum hexandrum Offers Radioprotection by Modulating Free Radical Flux: Role of Aryl-Tetralin Lignans. [Evid Based Complement Alternat...]
Podophyllum hexandrum Offers Radioprotection by Modulating Free Radical Flux: Role of Aryl-Tetralin Lignans.
Chawla R, Arora R, Singh S, Sagar RK, Sharma RK, Kumar R, Sharma A, Tripathi RP, Puri SC, Khan HA, et al. Evid Based Complement Alternat Med. 2006 Dec; 3(4):503-11. Epub 2006 Jun 21.
Review What has happened to the cathartic colon? [Gut. 1996]
Review What has happened to the cathartic colon?
Müller-Lissner S. Gut. 1996 Sep; 39(3):486-8.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Current status of podophyllotoxin for the treatment of genital warts.
Current status of podophyllotoxin for the treatment of genital warts.
Semin Dermatol. 1990 Jun ;9(2):148-51.

PubMed
PCDD/F formation from oxy-PAH precursors in waste incinerator flyash.
PCDD/F formation from oxy-PAH precursors in waste incinerator flyash.
Chemosphere. 2011 Dec ;85(11):1672-81. Epub 2011 Oct 22 .

PubMed
The role of Zic family zinc finger transcription factors in the proliferation an...
The role of Zic family zinc finger transcription factors in the proliferation and differentiation of retinal progenitor cells.
Biochem Biophys Res Commun. 2011 Nov 11 ;415(1):42-7. Epub 2011 Oct 15 .

PubMed
The role of reelin gene polymorphisms in the pathogenesis of Alzheimer's disease...
The role of reelin gene polymorphisms in the pathogenesis of Alzheimer's disease in a Greek population.
J Biol Regul Homeost Agents. 2011 Jul-Sep ;25(3):351-8.

PubMed
Advances in the use of stem cells and tissue engineering applications in bone re...
Advances in the use of stem cells and tissue engineering applications in bone repair.
Curr Stem Cell Res Ther. 2012 Mar ;7(2):122-6.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: